PW01-027 – Predictors and survival of FMF related amyloidosis
نویسندگان
چکیده
Objectives Compare the amyloidosis group to only proteinuria group for biochemical, demographic and some other features such as flow-mediated dilation (FMD), to understand which markers may affect or help prediction of amyloidosis. We also evaluated the effects of elevated ADMA levels and impaired FMD responses on the survival time of CVD free period in two distinct groups with severe proteinuria, secondary amyloidosis (SA) versus primary glomerulopathy. We proposed that increased ADMA synthesis in amyloidosis induced endothelial damage may contribute part of the mechanism by which proteinuria increases cardiovascular morbidity and mortality.
منابع مشابه
PW01-016 – Are different disease subtypes present in FMF
Introduction Familial Mediterranean fever (FMF) is an auto-inflammatory disorder characterized by self limited attacks of fever and serositis. The disease expression may be different in different ethnic groups and patients with certain MEFV mutations may be prone to have more severe disease and a greater probability of developing amyloidosis (1). Recently we showed that amyloidosis is the only ...
متن کاملFMF Genotype-phenotype correlation in Iranian Azeri Turks: Association between M694V/R761H mutation and amyloidosis
Objective(s):Familial Mediterranean fever (FMF), an inherited autosomal recessive disorder, is frequently present among individuals of Mediterranean origin. Differences in the clinical manifestations of FMF between different ethnic groups have been documented. The aim of the present study was to determine the most common characteristics of FMF and the relationship between clinical findings and ...
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Methods The study cohort involved 155 FMF patients (male/female 87/68). Mean age was 33,6±11,8 years in the patients group without renal amyloidosis (45 men, 35 women, n=80) and 37,8±7,4 years in the patients group with amyloidosis (42 men, 33 women, n=75). All the patients had symptoms related to the respiratory system, such as pleuritic chest pain with or without cough, dyspnea, chest tightne...
متن کاملP01-027 – Normal HRV in colchicine-resistant FMF patients
Introduction The relationship between autonomic nervous system (ANS) dysfunction and familial Mediterranean fever (FMF) is controversial. Heart rate variability (HRV) is a powerful, simple and reliable technique for the evaluation of ANS dysfunction. Recently, we reported on normal HRV parameters, suggestive of normal ANS function, in patients with uncomplicated FMF. Also, we reported on an ass...
متن کاملPW01-037 – Amyloidosis probability depending on MEFV type
Methods 69 FMF patients (37 with amyloidosis, 32 – without amyloidosis) were investigated. All 69 patient underwent molecular-genetic investigation (PCR method), 9 different mutant combinations of MEFV gene were detected: 3 homozygous M694V/M694V(AA) in 25 patients, M680I/ M680I(CC) in 4, V726A/V726A(BB) in 1, 5 compound heterozygous M694V/V726A(AB) in 17, M694V/M680I (AC) in 9, V726A/M680I(BC)...
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